Patients with chronic hepatitis B (CHB) are at risk of developing hepatocellular carcinoma (HCC) during treatment with nucleos(t)ide analogs (NAs). Several factors, including abnormal ALT levels during NA treatment, are associated with HCC risk; however, the mechanisms of ALT abnormalities remain unknown. Here, deletions in the preS1/2 region of the hepatitis B virus (HBV) genome were evaluated in the context of persistent ALT...

Anisakis is a parasite that is found in many marine products and can cause anisakiasis when present in fish consumed raw. The most common way to prevent anisakiasis is to freeze the fish, but this causes a noticeable decrease in the quality of the fish when eaten as sashimi. Although no practical method of killing anisakis other than freezing has been found, we have now succeeded in inactivating anisakis inside the fish meat b...