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The DnaA N ‐terminal domain interacts with Hda to facilitate replicase clamp‐mediated inactivation of DnaANARA Subscribed
Summary DnaA activity for replication initiation of the E scherichia coli chromosome is negatively regulated by feedback from the DNA ‐loaded form of the replicase clamp. In this process, called RIDA (regulatory inactivation of DnaA ), ATP ‐bound DnaA transiently assembles into a complex consisting of Hda and the DNA –clamp, which promotes inter‐ AAA + domain association between Hda and DnaA and stimulates hydrolysis of DnaA ‐...
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