Kenneth L. Cole results 19
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The Toxicology Investigators Consortium 2023 Annual ReportNARA Subscribed
The Toxicology Investigators Consortium 2022 Annual ReportNARA Subscribed
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Human landscape modification and expansion of tropical woodland in southern Arabia during the mid‐Holocene from rock hyrax middensNARA Subscribed
Aim Dryland ecosystems, such as those in southern Arabia, are particularly vulnerable to climate and land‐use change. Aridification and human subsistence changes at the end of the Holocene Humid Period at 6–4 ka have been used as an iconic example for evaluating such impacts to resilience of arid systems. Although records of ancient environments can provide critical insight into the biotic and abiotic mechanisms that alter eco...
Vegetation Response to Early Holocene Warming as an Analog for Current and Future ChangesNARA Subscribed
Temperatures in southwestern North America are projected to increase 3.5–4 °C over the next 60–90 years. This will precipitate ecological shifts as the ranges of species change in response to new climates. During this shift, rapid‐colonizing species should increase, whereas slow‐colonizing species will at first decrease, but eventually become reestablished in their new range. This successional process has been estimated to req...
Geographical and climatic limits of needle types of one‐ and two‐needled pinyon pinesNARA Subscribed
Aim The geographical extent and climatic tolerances of one‐ and two‐needled pinyon pines ( Pinus subsect. Cembroides ) are the focus of questions in taxonomy, palaeoclimatology and modelling of future distributions. The identification of these pines, traditionally classified by one‐ versus two‐needled fascicles, is complicated by populations with both one‐ and two‐needled fascicles on the same tree, and the description of two...
Ploidy race distributions since the Last Glacial Maximum in the North American desert shrub, Larrea tridentataNARA Subscribed
A classic biogeographic pattern is the alignment of diploid, tetraploid and hexaploid races of creosote bush ( Larrea tridentata ) across the Chihuahuan, Sonoran and Mohave Deserts of western North America. We used statistically robust differences in guard cell size of modern plants and fossil leaves from packrat middens to map current and past distributions of these ploidy races since the Last Glacial Maximum (LGM). Glacial/e...
Holocene Climate in the Western Great Lakes National Parks and Lakeshores: Implications for Future Climate ChangeNARA Subscribed
We reconstruct Holocene climate history ( last 10,000 years) for each of the U.S. National Park Service units in the western Great Lakes region in order to evaluate their sensitivity to global warming. Annual precipitation, annual temperature, and July and January temperatures were reconstructed by comparing fossil pollen in lake sediment with pollen in surface samples, assuming that ancient climates were similar to modern cli...
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