Tick-borne Neoehrlichia mikurensis is the cause of neoehrlichiosis, an infectious disease that features fever and vascular events. Compromised B-cell immunity is a risk factor for severe neoehrlichiosis, indicating the importance of antibodies in host defense. The development of serological assays has been hampered by the difficulty of culturing these intracellular bacteria. Here we present the first serological test for N. mi...

Although groundwater serves as the predominant source of drinking water across many rural regions and certain urban areas of Rwanda, little is known about this resource. Anthropogenic impacts, such as faecal contamination, as well as geogenic water quality problems, including elevated arsenic, fluoride, iron, and manganese, are among the issues of concern for groundwater quality in Rwanda. Long-term groundwater monitoring can...

Purpose The tick-borne bacterium Neoehrlichia mikurensis causes the infectious disease neoehrlichiosis in humans. Vascular endothelium is one of the target cells of the infection. Neoehrlichiosis patients with compromised B cell immunity present with more severe inflammation than immunocompetent patients. The aim of this study was to compare the cytokine profiles of immunocompetent and immunosuppressed patients with neoehrlich...