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Springer Nature1
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Translational Stroke Research1
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20231
Kenneth Schechtman results 1 · Newest (Page 1/1, per page 25)
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Recombinant Human Perlecan DV and Its LG3 Subdomain Are Neuroprotective and Acutely Functionally Restorative in Severe Experimental Ischemic StrokeNARA Subscribed
Translational Stroke Research · 2023 · Vol. 14 · Issue 6 · Springer
Ifechukwude Joachim Biose; Ibolya Rutkai; Bryan Clossen; Gary Gage; Kenneth Schechtman; H. Davis Adkisson; Gregory J. Bix
Despite recent therapeutic advancements, ischemic stroke remains a major cause of death and disability. It has been previously demonstrated that ~ 85-kDa recombinant human perlecan domain V (rhPDV) binds to upregulated integrin receptors (α2β1 and α5β1) associated with neuroprotective and functional improvements in various animal models of acute ischemic stroke. Recombinant human perlecan laminin-like globular domain 3 (rhPDV...
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