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The fusion of therapeutic proteins to the Fc domain of monoclonal antibodies (mAbs) generally improves the proteins' pharmacokinetic (PK) characteristics, extending in vivo half-lives due to the binding of the Fc domain to the FcRn receptor. Yet, several of these Fc-fusion biologics have been observed to have unexpected rapid clearance associated with non-specific off-target binding. Variability in non-specific clearance is of...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
The Cost of Antivenom: A Cost Minimization Study using the North American Snakebite RegistryNARA Subscribed
Envenomation is a global health issue, with over 9,000 encounters managed in the United States yearly. The introduction of immunoglobulin fragment antivenom has reduced the risk of hypersensitivity. This study compares treatment costs of crotaline envenomation using the Fab and F(ab’) 2 antivenoms as reported to the North American Snakebite Registry (NASBR), a nationwide surveillance tool. Methods This was a retrospective anal...
The Toxicology Investigators Consortium 2023 Annual ReportNARA Subscribed
Salinity is an increasing problem in coastal areas affected by saltwater intrusion, with deleterious effects on tree health and forest growth. Ectomycorrhizal (ECM) fungi may improve the salinity tolerance of host trees, but the impact of external potassium (K + ) availability on these effects is still unclear. Here, we performed several experiments with the ECM fungus Paxillus ammoniavirescens and loblolly pine ( Pinus taeda...
The Toxicology Investigators Consortium 2022 Annual ReportNARA Subscribed
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volumeNARA Subscribed
The concept of age acceleration, the difference between biological age and chronological age, is of growing interest, particularly with respect to age-related disorders, such as Alzheimer’s Disease (AD). Whilst studies have reported associations with AD risk and related phenotypes, there remains a lack of consensus on these associations. Here we aimed to comprehensively investigate the relationship between five recognised meas...
The scale of the Deepwater Horizon disaster was and is unprecedented: geographic extent, pollutant amount, countermeasure scope, and of most relevance to this Research Topic issue, range of ecotypes affected. These ecotypes include coastal/nearshore, continental shelf, deep benthic, and open-ocean domains, the last of which is the subject of this synthesis. The open-ocean ecotype comprises ~90% of the volume of the Gulf of Mex...