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Springer Nature1
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GeroScience1
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20251
Krish Patel results 1 · Newest (Page 1/1, per page 25)
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Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 (elamipretide) and development of a high-throughput machine learning-driven imaging pipeline for cerebromicrovascular protection therapeutic screeningNARA Subscribed
GeroScience · 2025 · Vol. 47 · Issue 3 · Springer
Roland Patai; Krish Patel; Boglarka Csik; Rafal Gulej; Raghavendra Y. Nagaraja; Dorina Nagy; Siva Sai Chandragiri; Santny Shanmugarama; Kiana Vali Kordestan; Mark Nagykaldi; Shoba Ekambaram; Anna Ungvari; Andriy Yabluchanskiy; Stefano Tarantini; Zoltan Benyo; Anna Csiszar; Zoltan Ungvari; Adam Nyul-Toth
Cerebral microhemorrhages (CMHs, also known as cerebral microbleeds) contribute to vascular cognitive impairment and dementia (VCID), with aging and hypertension being key risk factors. Mitochondrial oxidative stress is a hallmark of cerebrovascular aging, leading to endothelial dysfunction. This study tests the hypothesis that increased mitochondrial oxidative stress contributes to age-related CMH susceptibility and evaluates...
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