The pharmaceutical manufacturing industry faces significant challenges in integrating diverse data sources due to multi-generational equipment, varied technology stacks, and fragmented communication protocols. These challenges hinder scalability, increase technical effort, and limit the adoption of advanced analytics and AI-driven solutions. This paper introduces the Factory Integration Layer (FIL), a scalable, event-driven pl...

Introduction Rheumatoid arthritis (RA) arises from a complex inflammatory network involving cytokines, kinases, and matrix degrading enzymes. Methotrexate is the clinical standard but is limited by poor pharmacokinetics and a narrow mechanism. Methodology This study evaluates six polyphenols sinapic acid, catechin, galangin, piceatannol, umbelliferone, and pinocembrin against fifteen validated RA targets and benchmarks them ag...