G protein-coupled receptors strongly modulate neuronal excitability but there has been little evidence for G protein mechanisms in genetic epilepsies. Recently, four patients with epileptic encephalopathy (EIEE17) were found to have mutations in GNAO1, the most abundant G protein in brain, but the mechanism of this effect is not known. The GNAO1 gene product, Gα o , negatively regulates neurotransmitter release. Here, we repor...

Ecosystem management demands simultaneous consideration and integration of ecosystem services in monitoring, planning, and management activities, but specialization has led to independently developed traditions in wildlife biology and management and forestry. We drew on the literature to explore the use of filters in wildlife conservation and ecological classification systems in forest management and to ask the question, “Can...