The in vitro micronucleus (MN) test (OECD TG 487) has become the gold standard in various regulatory silos for assessing compounds for their potential to cause clastogenicity. Its main advantages are the reproducibility and robustness, as well as the ability to investigate both structural and numerical chromosome damage, i.e. clastogenicity and aneuploidy. A disadvantage, however, can be seen in the resource-intensive microsco...

Genotoxicity data are mainly interpreted in a qualitative way, which typically results in a binary classification of chemical entities. For more than a decade, there has been a discussion about the need for a paradigm shift in this regard. Here, we review current opportunities, challenges and perspectives for a more quantitative approach to genotoxicity assessment. Currently discussed opportunities mainly include the determina...

Cities are considered important refuges for insect pollinators. This has been shown repeatedly for wild bees, but may also be true for other diverse taxa such as hoverflies. However, our understanding of how urban environmental filters shape pollinator species communities and their traits is still limited. Here, we used wild bee and hoverfly species, communities and their functional traits to illustrate how environmental filte...

Summary Subsurface ecosystems like groundwater harbour diverse microbial communities, including small‐sized, putatively symbiotic organisms of the Candidate Phyla Radiation, yet little is known about their ecological preferences and potential microbial partners. Here, we investigated a member of the superphylum Microgenomates ( Cand . Roizmanbacterium ADI133) from oligotrophic groundwater using mini‐metagenomics and monitored...