Introduction Systemic inflammation and endothelial dysfunction are potentially modifiable factors implicated in Alzheimer’s disease (AD), which offer potential therapeutic targets to slow disease progression. Methods We investigated the relationship between baseline circulating levels of inflammatory (TNF-α, IL-1ß) and endothelial cell markers (VCAM-1, ICAM-1, E-selectin) and 18-month cognitive decline (ADAS-cog12) in 266 mild...

The fatigue life of ship structures is typically based on deterministic methods in which underlying uncertainties are only implicitly taken into account and not explicitly reflected. Guidance for a probabilistic assessment is provided in class documents, but the methodology is too time consuming to apply in design practice. This paper proposes a novel approach based on DNV-CG-0129 to incorporate uncertainties and consequences...

Ecological carryover effects, or delayed effects of the environment on an organism's phenotype, are central predictors of individual fitness and a key issue in conservation biology. Climate change imposes increasingly variable environmental conditions that may be challenging to early life‐history stages in animals with complex life histories, leading to detrimental physiological and fitness effects in later life. Yet, the late...

We used a field experiment to assess the individual and combined effects of removing top predators and enriching water column nutrients (nitrogen‐N and phosphorus‐P) on seagrass ecosystem structure and function. Experiments were conducted in turtlegrass ( Thalassia testudinum ) habitats in St. Joseph Bay, FL, an aquatic preserve in the northern Gulf of Mexico that exhibits low ambient nutrient concentrations and contains abund...