N -nitrosamine (NA) impurities in pharmaceuticals represent “cohort of concern” compounds under ICH M7(R2), due to their mutagenic/carcinogenic potential, involving cytochrome P450 (CYP)-mediated metabolic activation. Increasing interest in mammalian cell-based genotoxicity/mutagenicity assays prompted our assessment of the in vitro alkaline comet assay regarding its predictive power for NAs. Here, precision-cut liver slices (...

Background Resilience in aging—the capacity to maintain cognition and function despite neuropathology—has been described through cognitive reserve, brain reserve, and maintenance. The dynamic Neurocognitive Adaptation (dNA) framework expands these constructs by defining resilience as a lifelong process of adaptive engagement across cognitive, physical, creative, and social domains that shape neural integrity and cognitive outc...

Migratory birds are inherently vagile, a strategy that may reduce the impacts of habitat loss and fragmentation on genetic diversity. However, specialist resource requirements and range‐edge distribution can counteract these benefits. The European nightjar ( Caprimulgus europaeus ) is a long‐distance migratory bird and resource specialist. Like other long‐distance migrants, nightjar populations have declined across the British...

Ecological theory predicts that consumers should be co‐limited by resource quantity and quality, given widespread consumer‐resource nutritional imbalances. We used 25 estimates of annual community secondary production (ACSP) of stream macroinvertebrates to assess the relative roles of basal resource quantity (leaf litter standing stock [LLSS]) and quality (% nitrogen and % phosphorus of leaf litter) in modulating patterns of p...

The crises of climate change and biodiversity loss are interlinked and must be addressed jointly. A proposed solution for reducing reliance on fossil fuels, and thus mitigating climate change, is the transition from conventional combustion‐engine to electric vehicles. This transition currently requires additional mineral resources, such as nickel and cobalt used in car batteries, presently obtained from land‐based mines. Most...