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This paper introduces a comprehensive Tropical Cyclone (TC) dataset based on China’s FengYun (FY) series geostationary satellite observations in the Western North Pacific (WNP), designated as FYSATTY. This innovative dataset integrates high-resolution geostationary meteorological satellite observations with best-track data, providing a unique resource for TC monitoring and analysis in the WNP region. FYSATTY is derived from in...
Antibody–drug conjugates (ADCs) represent a rapidly evolving therapeutic modality, combining the selective targeting of monoclonal antibodies with highly potent small molecule payloads. Their inherent structural complexity demands a sophisticated and multi-faceted bioanalytical approach spanning preclinical discovery through late-stage clinical development. This white paper, developed by the ADC Working Group of the AAPS bioan...
Precision measurement of the Ds*+-Ds+ meson mass differenceNARA Subscribed
Discovery of a Potent Small Molecule Antagonist of GRPR for the Treatment of PruritusNARA Subscribed
Persistent pruritus (itch) affects the quality of life, and many itch syndromes remain untreatable. Previously, we identified the gastrin-releasing peptide receptor (GRPR) playing a critical role in mediating histamine-independent itch signaling. In this study, we aimed to identify small-molecule GRPR antagonists to treat histamine-independent itch. Starting with the known small-molecule GRPR antagonist PD 176,252, we conducte...
Distinguishing climate change worry from state climate anxiety across 32 countries: implications for subjective wellbeingNARA Subscribed
The concepts of “climate change worry” and “climate change anxiety” are often used interchangeably in climate research, but they may reflect distinct emotional responses to climate change, which could potentially have different implications for public mental health. This research brief aims to empirically examine the differences between these two constructs by comparing their associations with key indicators of subjective well...
Distributed optical fibre sensing (DOFS) is a technology that enables continuous, real-time measurements of a range of environmental parameters along the length of a fibre optic cable. In this article, we review the recently emerged applications of DOFS techniques in physical oceanography and offer a perspective on the technology's potential for future growth within the field. The introduction of DOFS to physical oceanography...
Prof Stephen P. Long, FRS (1950–2025)NARA Subscribed