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E122Q rhodopsin: pigment microspectrophotometry, photoreceptor light responses, and bleaching adaptationNARA Subscribed
When the rhodopsin visual pigment of vertebrate rods absorbs light, photoisomerization of its 11- cis retinal chromophore to all-trans retinal triggers a conformational change, ultimately leading to the formation of metarhodopsin II (meta II), the active signalling state. Meta II initiates the phototransduction cascade, culminating in membrane hyperpolarization. To investigate how meta II lifetime shapes the rod photoresponse,...
The aetiology of frailty remains unknown. It has been hypothesised that individual differences in epigenetic mechanisms, particularly DNA methylation (DNAm), may help to explain why some individuals become frail while others do not. Relating epigenetic measures to transitions in age-related frailty in individual patients requires longitudinal studies over many years. To overcome this barrier, we study associations between DNAm...
Discovery of a Potent Small Molecule Antagonist of GRPR for the Treatment of PruritusNARA Subscribed
Persistent pruritus (itch) affects the quality of life, and many itch syndromes remain untreatable. Previously, we identified the gastrin-releasing peptide receptor (GRPR) playing a critical role in mediating histamine-independent itch signaling. In this study, we aimed to identify small-molecule GRPR antagonists to treat histamine-independent itch. Starting with the known small-molecule GRPR antagonist PD 176,252, we conducte...
Non‐native pink salmon Oncorhynchus gorbuscha carcasses benefit native benthic macroinvertebratesNARA Subscribed
The invasion of the North Atlantic by pink salmon Oncorhynchus gorbuscha has raised concerns regarding their impact on coastal rivers. Although the influence of marine‐derived nutrients from returning adult O. gorbuscha on rivers in their native range has received much attention, the ecological consequences of invasive O. gorbuscha for ecosystems outside the native range are largely unknown. To investigate the impact on the de...
Boat strikes injure and kill large numbers of Florida manatees ( Trichechus manatus latirostris ) each year. Management actions taken to mitigate this threat can be potentially enhanced by consideration of manatee cognitive processes. The role of cognition in marine mammal conservation has received little consideration in the literature. Here, we integrate discoveries from laboratory research on auditory sensory processes and...
Ecovoltaic wild bee pollinator habitat may be a key to habitat connectivity and pollination services in solar-agricultural landscapesNARA Subscribed
Photovoltaics is emerging as the most widespread renewable energy sources globally, yet with increased reliance on alternative energy sources, concerns for land usage have been increased as well. Photovoltaic farms, while typically converted from agricultural farms, have the ability to be key multipurpose lands, incorporating agricultural or conservation initiatives in the same area. While developers advertise increased pollin...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
Exploring Marine Mammal Cognition as a Conservation ToolNARA Subscribed
Cognition is an animal's real‐time adaptation system for responding to change. Rapid environmental change, often anthropogenic, is expanding the range and severity of challenges confronting wild animals. Effective conservation requires a multifaceted approach that includes animals' capacities. Large‐brained, long‐lived animals such as marine mammals often have extensive capability to adaptively modify their behavior due to the...
Age-related change in skeletal muscle strength, size, and adiposity over 18 years in Caribbean menNARA Subscribed
Declines in muscle strength outpace declines in muscle mass with age, so factors like muscle adiposity (i.e., myosteatosis) may contribute to strength loss. We describe intermuscular adipose tissue (IMAT) and grip strength over 18 years among middle-aged and older African Caribbean men. We hypothesized that increases in IMAT precede the loss of muscle area and strength, and that increased IMAT is independently associated with...