L. Hunt results 221
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Total plasma N-glycomic patterns of COVID-19 diseaseNARA Subscribed
Total plasma N -glycans alter in disease states, with few studies focused on COVID-19. A discovery cohort of 310 COVID-19 patients, replicated with 97 COVID-19 patients and tested with 100 COVID-19 patients, was used to unearth the N -glycans capable of distinguishing infection, as well as prognosis of intensive care unit (ICU) admission and mortality. All significant bisected glycans were decreased in patients compared to con...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Century‐Scale Changes in the Feeding Patterns of Demersal Fish Species in the Western North SeaNARA Subscribed
Understanding the extent and magnitude of change in marine food webs requires historical data that predates modern monitoring efforts. Such information can provide invaluable insights into the longer‐term impacts of altered trophic interactions, yet it is rarely incorporated into marine policy frameworks. Using multiple stomach records spanning over a century, we investigated long‐term changes in the diet composition of six de...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Second opinions for cancer diagnosis are frequently sought although they are of variable value to the patient and their primary oncologist. The oncology opinion service launched in 2020 without barriers frequently associated with conventional health systems. Financial barriers were removed; neither patient nor insurance was billed. The service is free of charge. Consult-only service provision, without providing therapy, allows...
Background and aims Water scarcity due to increasing climate variability means improved drought tolerance in crop plants is more urgent. Addition of organic wastes could enhance crop drought tolerance through improved nutrition or increased soil water holding capacity. However, their effect on crop water relations, mediated by plant beneficial soil microbes, remains less well-studied. This study aims to understand how applicat...
Three Decades of World Recreational Fishing Conferences: What Have We Learned About the Dynamics of Recreational Fisheries?NARA Subscribed
Recreational fishing extends beyond catching fish, by connecting individuals with nature, generating environmental stewards, and contributing to local, regional, and national economies. Multi‐ and inter‐disciplinary research, integrative management, and policy approaches can support better assessment of potential impacts of recreational fishing on social‐ecological systems. Transdisciplinary thinking supports managing recreati...
The genetic architecture of temperature-induced partial fertility restoration in A1 cytoplasm in sorghum (Sorghum bicolor (L.) Moench)NARA Subscribed
Key message High-temperature-induced partial fertility in CMS sorghum is controlled by multiple genes that are distinct from genes involved in fertility restoration, contributing to reduced diversity in elite females. Abstract Cytoplasmic male sterility (CMS) is used for commercial production of hybrid seed in sorghum. CMS-based hybrid breeding systems require female parental lines (CMS lines) to remain male sterile to prevent...
Connectivity Benefits Most Woodland Invertebrate Species but Only in Landscapes With Low Woodland CoverNARA Subscribed
Connectivity is widely assumed to benefit biodiversity, but this has not been extensively quantified across multiple taxa and landscapes. Focusing on the UK, where woodland cover is low (13%), we analysed species occurrence records from citizen science for over 800 broadleaf woodland‐associated invertebrate species from 15 taxonomic groups in relation to woodland cover and connectivity. Overall, increased woodland connectivity...