L. Maya results 117
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Coral acclimatization to novel, co-varying stressors is associated with fitness trade-offsNARA Subscribed
Reef-building corals are under pressure to acclimatize and/or adapt to multiple co-occurring stressors, including climate change and declines in water quality. However, their capacity to do so is largely unknown. Yet, some corals naturally persist in habitats with multi-stressor conditions which can provide crucial insight into coral adaptive capacity under future ocean conditions. To assess the role of phenotypic plasticity a...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Small Molecules to Elevate Rab7-GTPase Activity and Lower Cholesterol Accumulation in Niemann-Pick Type C DiseaseNARA Subscribed
Purpose Niemann-Pick type C (NPC) disease caused by mutations in cholesterol transporters NPC1 or NPC2 is characterized by cholesterol accumulation in late endosomes/lysosomes (LE/Lys). The activation of alternative cholesterol export routes that can bypass NPC1/2 deficiency could provide therapeutic opportunities. We previously demonstrated that gene depletion of the Rab7-GTPase activating protein (GAP) TBC1D15, which hydroly...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...
Multiple Community Properties Drive Ecosystem Resistance and Resilience to Extreme Climate Events Across Mesic GrasslandsNARA Subscribed
Ecosystem resistance and resilience to extreme climate events is impacted by community properties, including biodiversity. However, the relative importance of species richness, evenness and dominance is debated and is further modulated by global change factors such as nutrient addition. Using nearly 40 years of data from naturally‐assembled plant communities at three Long‐Term Ecological Research sites, we found that while spe...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Filter feeding by oysters reduces disease transmission in a marine host–parasite systemNARA Subscribed
As a mechanism of the dilution effect, predation and filter feeding on parasitic propagules are hypothesized to reduce transmission to susceptible hosts and alter host–parasite interactions. In marine systems, the effect of other community members on the disease dynamics of microparasites in their suitable hosts is poorly known. In a coastal estuarine host–parasite system, we examined how eastern oysters, Crassostrea virginica...
Aging humans and non-human primates both exhibit a similar pattern of cognitive decline beginning in middle age that is characterized by progressive impairments in rule learning, executive function, and working and recognition memory—functions often associated with dysfunction of prefrontal and medial temporal lobe regions. The heterogeneity and inter-subject variability in aging and age-related cognitive impairments present c...
Terrigenous inputs link nutrient dynamics to microbial communities in a tropical lagoonNARA Subscribed
Nutrient availability drives community structure and ecosystem processes, especially in tropical lagoons that are typically oligotrophic but often receive allochthonous inputs from land. Terrestrially derived nutrients are introduced to tropical lagoons by surface runoff and submarine groundwater discharge, which are influenced by seasonal precipitation. However, terrigenous inputs presumably diminish along the onshore–offshor...