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Tobacco use remains the leading preventable cause of cancer mortality worldwide, with marked disparities in cancer incidence and outcomes across racial and ethnic groups. This study investigates the genetic determinants of tobacco carcinogen metabolism among smokers, focusing on ancestry-informative markers (AIMs) near genes involved in metabolic activation (Phase I), detoxification (Phase II), and transport (Phase III) of tob...
The Effects of Land‐Use Dynamics on Avian Phylogenetic Diversity Across Island EcosystemsNARA Subscribed
Aim To test whether forest extent and recent forest‐cover change are associated with avian phylogenetic diversity and community‐level evolutionary value across islands. Location Seven islands spanning Borneo and Wallacea in the Malay Archipelago. Taxon Terrestrial birds. Methods We sampled 1410 sites (2010–2022). We calculated phylogenetic diversity (PD), mean phylogenetic distance (MPD), mean nearest taxon distance (MNTD) and...
Precision measurement of the Ds*+-Ds+ meson mass differenceNARA Subscribed
Crop mixtures: yield responses to climate and management and impacts on seed and soil chemical composition in a Scottish-based studyNARA Subscribed
Introduction Crop mixtures can be an important part of the toolkit for maintaining crop production while addressing the climate and nature crises. However, uncertainties around some issues may prevent their uptake. Research question This study addressed several uncertainties, specifically the response of mixture yields to climate and management, and the impacts of mixed cropping on seed chemical composition, soil carbon and nu...
Climate change is increasing stream temperatures globally, likely impacting stream ecosystem processes. We conducted a stream warming experiment at the Notre Dame Experimental Mesocosm Facility using N = 24 recirculating mesocosms to examine the effect of warming on biofilm colonization of organic and inorganic substrata and rates of nutrient removal. We conducted an experiment with three temperature treatments (20°C, 23°C, an...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Peripheral microRNA signature in genetic frontotemporal dementia—findings from the GENFI initiativeNARA Subscribed
Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...
Top-down Control by Ribbed Mussels (Geukensia demissa) on Plankton Communities in Southeastern U.S. Salt MarshesNARA Subscribed
Benthic grazers and suspension feeders, such as oysters and mussels, may play a disproportionate role in controlling algal biomass and plankton community composition in estuarine systems. Nonetheless, their effects on plankton communities remain poorly understood across environmental contexts, in part from a paucity of in situ measurements. Here, we conducted in situ manipulative field experiments to evaluate the effects of th...