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Bacteria are fundamental to coral health and resilience, though a dearth of knowledge exists on the formation of the coral microbiome in early life history stages. Although this initial microbial consortium is thought to hold key roles throughout development, its sparsity is easily obscured by environmental background microbiota. This opacity renders accurate studies of the early coral microbiome difficult, and limits applicat...
Species‐specific processing of fluorescent dissolved organic matter by Caribbean spongesNARA Subscribed
Coral reefs are biodiverse and productive ecosystems that are found in typically oligotrophic environments. Many studies have attempted to explain this paradox by demonstrating that microbial symbionts expand metabolic capabilities of host animals. However, few studies have determined if and how coexisting organisms and their symbiotic microbial communities partition available dissolved organic matter. To address this question...
The purpose of this study was to investigate the prevalence of relative age effects (RAEs) within and between U18, U21 and professional senior squads, that compete in the highest (respective) leagues within England. Birthdate, playing position and age (years) of U18 ( n = 487), U21 ( n = 350), and senior ( n = 396) players from squads competing in the highest divisions of their respective age groups were obtained. Moreover, na...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Resolving Heterogeneity in the Diagnosis of Alzheimer’s Disease and its Progression Using Multimodal DataNARA Subscribed
Alzheimer’s disease (AD) is a complex and diverse illness that makes early detection extremely difficult. Most existing research utilizes data to identify biomarkers and more homogeneous subgroups to improve the detection, prediction of progression, and prognosis of AD. However, AD still suffers from a lack of appropriate biomarkers for early symptom detection and blurred boundaries between different subgroups. Here, an unsupe...
Primate populations worldwide are experiencing rapid declines due to habitat loss, degradation, and overexploitation. These pressures are particularly severe across sub-Saharan Africa and the Gulf of Guinea biodiversity hotspot, which supports several threatened and endemic species. The Ebo-Makombe-Ndokbou forests in southwestern Cameroon contain critical habitat for several of these species, including the Critically Endangere...