Chung-Jansen syndrome is a neurodevelopmental disorder characterized by intellectual disability, behavioral problems, obesity and dysmorphic features. It is caused by pathogenic variants in the PHIP gene that encodes for the Pleckstrin homology domain-interacting protein, which is part of an epigenetic modifier protein complex. Therefore, we hypothesized that PHIP haploinsufficiency may impact genome-wide DNA methylation (DNAm...

Objective Several studies investigated the link between agricultural occupational exposures and DNA damage, in an attempt to bring elements of biological plausibility to the increased cancer risk associated with them. However, only a few of these studies focused on females. Methods The comet assay was performed on PBMC (Peripheral Blood Mononuclear Cells) samples from 245 females working in open field farming and cattle raisin...

Thirty migrating silver eels Anguilla anguilla were collected in a river system where algal blooms occurred yearly. Fifty per cent of eel livers were contaminated by microcystin‐LR (mean ± s . d . toxin level: 28·1 ± 22·4 ng g −1 ). Contaminated silver ( v. healthy) eels had lower fish condition. Consequences of this impact for the breeding potential of these migrating eels are discussed.