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Exploring Ayahuasca Multitarget Potential in Neuropsychiatric Disorders: Integrated Insights Towards Drug DiscoveryNARA Subscribed
Purpose of Review This review integrates evidence from the literature with network pharmacology tools to explore the decoction’s multitarget potential and provide multilevel insights into its therapeutic role in neuropsychiatric disorders. Recent Findings Neuropsychiatric disorders remain a significant health burden, underscoring the limitations of single-target pharmacotherapies and the urgent need for effective multitarget a...
Basal release of 6-cyanodopamine from rabbit isolated aorta and its modulation of vascular reactivityNARA Subscribed
6-Cyanodopamine (6-CYD) is a recently identified endogenous catecholamine that exerts positive chronotropic and inotropic actions, but its occurrence in vascular tissue and effects on vascular reactivity are unknown. In endothelium-intact and endothelium-denuded rabbit isolated aortic rings, we investigated the basal release of 6-CYD and its effects on aortic smooth muscle reactivity. 6-Cyanodopamine release was quantified by...
Macrourid species constitute the main bycatch in Southern Ocean toothfish longline fisheries. We report the first confirmed record of Whitson's grenadier, Macrourus whitsoni , in the South Georgia toothfish fishery. Mitochondrial cox1 DNA barcoding confirmed its presence in bycatch samples collected around South Georgia and the northern South Sandwich Islands, with approximately 1% divergence from its congener, M. caml . Haplo...
Introduction: Lung cancer remains one of the leading causes of death worldwide, accounting for approximately 1.8 million deaths annually. In this context, low health literacy is frequent and represents a barrier to effective education on screening and early detection. The aim of this study was to translate, culturally adapt, and validate the Lung CAM questionnaire for use in Brazil, enabling the assessment of population litera...
Fecal Microbiome Varies With Social Group, Age and Bovine Tuberculosis Infection in the European Badger ( Meles meles )NARA Subscribed
Host‐associated microbes are key components of animal health and physiology, with particular importance for determining responses to pathogen infection. The gut microbiota is highly variable at the individual level, being shaped by a multitude of factors including diet, social behaviour, and age. Yet the relative influence of these traits on microbiota composition, and the consequences of this variation for host responses to p...
Distribution and ecology of the four Macrourus species by‐caught in the longline fishery at South Georgia, Southern OceanNARA Subscribed
Although Macrourus species are the main by‐catch across Southern Ocean longline fisheries, including around South Georgia, the lack of species‐specific data has hindered effective management and ecological understanding. Aggregation of macrourids at genus level masks critical interspecific differences in life‐history strategies and vulnerabilities to fishing. Here, we provide the first comprehensive biological assessment of th...
We present a large-scale laboratory model of the Strait of Gibraltar that reproduces realistic topography, tidal forcing, stratification, and rotation, enabling controlled investigation of key exchange processes linking the Mediterranean Sea and Atlantic Ocean. Velocity and density measurements confirm dynamic similarity with ocean observations. Analysis of the flow near Camarinal Sill shows that bottom boundary layers are the...
The Interplay of Climate Change, Urbanisation, and Species Traits Shapes European Butterfly Population TrendsNARA Subscribed
Aim To examine how butterfly population trends respond to climate change and urbanisation at a continental scale, and whether responses differ between urban and rural environments. Location 869 sites across 12 European countries, spanning six bioclimatic zones. Time Period 1976–2021. Major Taxa Studied Butterflies (Lepidoptera). Methods We analysed long‐term monitoring data from > 8400 populations of 145 species representing a...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
The biomedical engineer’s pledge: overview and contextNARA Subscribed
Although biomedical engineering (BME) is a profession with ethical responsibilities comparable to those in medicine, it has, until now, lacked a counterpart to the Hippocratic Oath. While professional societies have established codes of ethics for biomedical engineers, these documents lack the symbolic and ceremonial significance of an oath or pledge. By contrast, the recitation of the Hippocratic Oath, or its modern version,...