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Epigenomic changes are a hallmark of aging, and DNA methylation (DNAm) has emerged as the most reliable molecular marker of an individual's age. Genome‐wide patterns of age‐associated hypo‐ and hypermethylation have been applied to generate predictive models (i.e., “epigenetic clocks”) capable of estimating chronological age in an increasingly diverse set of species including many mammals, a few birds, a reptile, and several b...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
Bacterial abscesses in whitespotted bamboo sharks ( Chiloscyllium plagiosum ) in managed careNARA Subscribed
Sixteen whitespotted bamboo sharks ( Chiloscyllium plagiosum ) with histologically similar bacterial abscesses were submitted to Northwest ZooPath from nine zoo and aquarium institutions over a 17‐year period. These abscesses were characterized by inflammatory cell infiltrates and necrosis with intralesional small, Gram‐positive, acid‐fast negative, cocci bacteria. The clinical presentation, histologic findings, and culture re...
Maintaining self-sustaining populations of zoo and aquarium collections can be challenged when natural reproduction fails within mixed-sex populations; however, reproductive success can sometimes be restored with the application of reproductive technologies. Among a population of three female and one male Zebra Sharks ( Stegostoma tigrinum ), production of young failed despite constant male presence with two of the females. To...
Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volumeNARA Subscribed
The concept of age acceleration, the difference between biological age and chronological age, is of growing interest, particularly with respect to age-related disorders, such as Alzheimer’s Disease (AD). Whilst studies have reported associations with AD risk and related phenotypes, there remains a lack of consensus on these associations. Here we aimed to comprehensively investigate the relationship between five recognised meas...
Systemic phaeohyphomycosis in splitnose rockfish ( Sebastes diploproa ) caused by Devriesia sp .NARA Subscribed
A novel pathogen was documented after two wild‐caught, juvenile, splitnose rockfish presented with buphthalmia, grey corneal endothelial plaques and evidence of uveitis. Cytologic evaluation of ocular contents revealed fungal hyphae. Histologic evaluation identified multiple fungal granulomas and granulomatous inflammation in the globes, periocular tissue and heart. Fungi were slender, hyphenated and branched at angles, had pa...
Hispaniola is a geotectonically complex island consisting of two palaeo‐islands that docked c. 10 Ma, with a further geological boundary subdividing the southern palaeo‐island into eastern and western regions. All three regions have been isolated by marine barriers during the late Cenozoic and possess biogeographically distinct terrestrial biotas. However, there is currently little evidence to indicate whether Hispaniolan mamm...
Ecological boundary detection using Bayesian areal womblingNARA Subscribed
The study of ecological boundaries and their dynamics is of fundamental importance to much of ecology, biogeography, and evolution. Over the past two decades, boundary analysis (of which wombling is a subfield) has received considerable research attention, resulting in multiple approaches for the quantification of ecological boundaries. Nonetheless, few methods have been developed that can simultaneously (1) analyze spatially...
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