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Springer Nature1
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Journal of Molecular Medicine1
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20231
Lars Hummitzsch results 1 · Newest (Page 1/1, per page 25)
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Large extracellular vesicles derived from human regulatory macrophages (L-EVMreg) attenuate CD3/CD28-induced T-cell activation in vitroNARA Subscribed
Journal of Molecular Medicine · 2023 · Vol. 101 · Issue 11 · Springer
Martin Albrecht; Lars Hummitzsch; Rene Rusch; Christine Eimer; Melanie Rusch; Katharina Heß; Markus Steinfath; Jochen Cremer; Fred Fändrich; Rouven Berndt; Karina Zitta
Macrophages belong to the innate immune system, and we have recently shown that in vitro differentiated human regulatory macrophages (Mreg) release large extracellular vesicles (L-EV Mreg ) with an average size of 7.5 μm which regulate wound healing and angiogenesis in vitro. The aim of this study was to investigate whether L-EV Mreg also affect the CD3/CD28-mediated activation of T-cells. Mreg were differentiated using blood...
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