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The deep ocean, while home to a remarkable diversity of life, remains one of the least understood environments on Earth. This profound lack of information hampers our ability to protect and manage deep-sea ecosystems effectively, especially as they face escalating threats from human activities such as resource extraction, pollution, and climate change. In light of these knowledge gaps, this study investigates the diversity of...
Electrical stimulation remains a promising but insufficiently standardized approach in regenerative medicine, as many in vitro studies lack physically defined stimulation systems and quantitative characterization of cellular electric-field exposure. Here, we present a measurement-based framework integrating real-time electrical recordings, impedance-informed simulations, and electrode characterization under experimental condit...
Functional expression of the ATP-gated P2X7 receptor in human iPSC-derived astrocytesNARA Subscribed
Activation of the ATP-gated P2X7 receptor (P2X7R), implicated in numerous diseases of the brain, can trigger diverse responses such as the release of pro-inflammatory cytokines, modulation of neurotransmission, cell proliferation or cell death. However, despite the known species-specific differences in its pharmacological properties, to date, most functional studies on P2X7R responses have been analyzed in cells from rodents o...
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