The biologically stable and highly toxic organophosphorus nerve agent (OP) VX poses a major health threat. Standard medical therapy, consisting of reactivators and competitive muscarinic receptor antagonists, is insufficient. Recently, two engineered mutants of the Brevundimonas diminuta phosphotriesterase (PTE) with enhanced catalytic efficiency ( k cat / K M = 21 to 38 × 10 6 M −1 min −1 ) towards VX and a preferential hydro...

Highly toxic organophosphorus nerve agents, especially the extremely stable and persistent V-type agents such as VX, still pose a threat to the human population and require effective medical countermeasures. Engineered mutants of the Brevundimonas diminuta phosphotriesterase (BdPTE) exhibit enhanced catalytic activities and have demonstrated detoxification in animal models, however, substrate specificity and fast plasma cleara...

Marine renewables represent a promising and innovative alternative source for satisfying the energy demands of growing populations while reducing the consumption of fossil fuels. Most technological advancements and energy yield assessments have focused on promoting the use of kinetic energy from tidal streams with flow velocities higher than 2.0 m s−1. However, slower-moving flows from ocean currents are recently explored due...