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NARA Subscribed1
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Springer Nature1
Journal
✓Purinergic Signalling1
Publication Year
20231
Li-Cheng Chen results 1 · Newest (Page 1/1, per page 25)
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Journal: Purinergic Signalling ×Author: Li-Cheng Chen ×Clear All Filters
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In silico identification of A1 agonists and A2a inhibitors in pain based on molecular docking strategies and dynamics simulationsNARA Subscribed
Purinergic Signalling · 2023 · Vol. 19 · Issue 1 · Springer
Guangya Xu; Shutao Zhang; Lulu Zheng; Zhongjiao Hu; Lijia Cheng; Lvlin Chen; Jun Li; Zheng Shi
Most recently, the adenosine is considered as one of the most promising targets for treating pain, with few side effects. It exists in the central nervous system, and plays a key role in nociceptive afferent pathway. It is reported that the A1 receptor (A1R) could inhibit Ca 2+ channels to reduce the pain like analgesic mechanism of morphine. And, A2a receptor (A2aR) was reported to enhance the accumulation of AMP (cAMP) and r...
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