Edwardsiella anguillarum causes Edwardsiellosis in fish, resulting in severe internal organ lesions and substantial economic losses in aquaculture. The limited efficacy of antibiotics in treating this disease, coupled with concerns regarding resistance and side effects, has driven interest in exploring fish vaccines. Various vaccine candidates derived from E. anguillarum, including inactivated cells and protein subunits, have...

Objective The intestinal epithelial barrier maintains gut homeostasis, and its disruption contributes to inflammatory diseases such as Inflammatory Bowel Diseases (IBD). Although barrier restoration is a promising therapeutic strategy, most current approaches target immune responses rather than epithelial function. Since barrier injury and repair progress through discrete phases, this study aimed to define time-resolved epithe...

Nervous necrosis virus (NNV) is the causative agent of viral nervous necrosis, otherwise known as viral encephalopathy and retinopathy in larval and juvenile marine fish worldwide. The pandemic outbreaks have caused nearly 100% mortality in hatcheries, leading to significant economic losses in the aquaculture industry. Since NNV attacks the insufficient immune competence fish at early developmental stages, there is an urgent n...

This study aims to explore the resistance mechanism of grass carp ( Ctenopharyngodon idella ) to heat stress (HS). Grass carp were cultured at 28°C, and then exposed to 30°C, 32°C or 34°C with a heating rate of 1°C/d, respectively. The results show that serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels and liver malondialdehyde (MDA) content significantly increased after HS. In contrast, liver total...