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Oxymatrine (OMT), a major alkaloid extracted from Sophora flavescens, has been widely recognized for its anti-inflammatory and anti-cancer properties. However, its precise neuroprotective mechanisms in cerebral ischemia/reperfusion (I/R) injury remain to be fully elucidated. In this study, we combined in vivo and in vitro models to investigate the therapeutic effects of OMT on cerebral I/R injury and glutamate-induced neuronal...
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