Li-Jun Ouyang results 68
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Androgen induces 3′UTR shortening of de novo lipogenesis genes by alternative polyadenylation in prostate cancer cellsNARA Subscribed
Alternative polyadenylation (APA) is a pervasive mechanism that is emerging as a formidable player in post-transcriptional regulation. The transcriptional landscape can be altered via APA in response to various stimulating factors. Using the PacBio single-molecule long-read sequencing method, we present for the first time the 3′UTR landscape and reveal a global increase of APA events in prostate cancer (PCa) LNCaP cells in res...
The North American Atlantic Coastal Ocean Margin (NAACOM) was recognized as an atmospheric carbon dioxide (CO 2 ) sink, with large uncertainties in its northern areas due to complex dynamics in controlling the spatiotemporal variability of surface partial pressure of CO 2 ( p CO 2 ) and limited p CO 2 observations. Here, we used a regional reconstructed product to investigate the spatial and seasonal variability of p CO 2 and...
Silent information regulator 5 (SIRT5) is the fifth member of the sirtuin family, which is mainly expressed in mitochondrial matrix. SIRT5 plays a key role in metabolism and antioxidant responses, and is an important regulator for maintaining intracellular homeostasis. Given its involvement in multiple cellular processes, dysregulation of SIRT5 activity is associated with a variety of diseases. This review explores the structu...