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Li-Lin Lin results 14 · Newest (Page 1/1, per page 25)
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Targeting Pyruvate Kinase M2: Signal Transduction Pathways and Exploration of Cancer Therapeutic StrategiesNARA Subscribed
The AAPS Journal · 2026 · Vol. 28 · Issue 4 · Springer
Jiaxing Wang; Wenyu Zhang; Nana Shen; Pan Li; Wentao Xie; Shuya Wang; Ye Cheng; Lin Zhao; Yang Yang; Huadong Zhao
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Model-informed Drug Development (MIDD) Approach to Support Biopharmaceutical Development of IberdomideNARA Subscribed
The AAPS Journal · 2025 · Vol. 27 · Issue 4 · Springer
Caroline Sychterz; Ping Chen; Ajay Saxena; Hongxia Lin; Lu Chen; Yan Li; Lu Gaohua; Yiming Cheng
Iberdomide is a BCS III CELMoD™ agent currently under development for treatment of multiple myeloma. Five formulations were used during clinical development, starting with active ingredient in gelatin capsule (AIC), followed by subsequent formulations in gelatin (F1), HPMC capsules (F2 and F3), and finally the intended commercial form (ICF). A food effect study with the Phase I AIC formulation showed no food effect and two rel...
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A Facile Way to Enhance the Therapeutic Efficacy of Hydrophobic Drugs via Amorphous Solid DispersionsNARA Subscribed
The AAPS Journal · 2025 · Vol. 27 · Issue 2 · Springer
Ning Tao; Zihui Yan; Xin Wang; Yuhui Wang; Li Ji; Lin Qiu; Pengfei Cui; Jianhao Wang
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Prediction of Drug-Drug Interactions for Highly Plasma Protein Bound CompoundsNARA Subscribed
The AAPS Journal · 2024 · Vol. 27 · Issue 1 · Springer
David Tess; Makayla Harrison; Jian Lin; Rui Li; Li Di
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Blood–Brain Barrier Permeability is Affected by Changes in Tight Junction Protein Expression at High-Altitude Hypoxic Conditions—this may have Implications for Brain Drug TransportNARA Subscribed
The AAPS Journal · 2024 · Vol. 26 · Issue 5 · Springer
Guiqin Liu; Qian Wang; Lu Tian; Mengyue Wang; Delong Duo; Yabin Duan; Yue Lin; Junjun Han; Qiangqiang Jia; Junbo Zhu; Xiangyang Li
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Novel Selective Quantification of Zinpentraxin Alfa Biotherapeutic in the Presence of Endogenous Isomer in Plasma Samples of Idiopathic Pulmonary Fibrosis Patients Using Immunoaffinity LC–MSNARA Subscribed
The AAPS Journal · 2023 · Vol. 26 · Issue 1 · Springer
Maoyin Li; Audrey Arjomandi; Xiaowei Sun; Erhu Lu; Tulika Tyagi; WeiYu Lin; Saloumeh K. Fischer; Surinder Kaur; Keyang Xu
Idiopathic pulmonary fibrosis (IPF) is a progressive fatal interstitial lung disease that affects three million patients worldwide and currently without an effective cure. Zinpentraxin alfa, a recombinant human pentraxin-2 (rhPTX-2) protein, has been evaluated as a potential drug candidate for the treatment of IPF. Clinical pharmacokinetic analysis of zinpentraxin alfa has been challenging historically due to interference from...
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Biopharmaceutics Applications of Physiologically Based Pharmacokinetic Absorption Modeling and Simulation in Regulatory Submissions to the U.S. Food and Drug Administration for New DrugsNARA Subscribed
The AAPS Journal · 2021 · Vol. 23 · Issue 2 · Springer
Fang Wu; Heta Shah; Min Li; Peng Duan; Ping Zhao; Sandra Suarez; Kimberly Raines; Yang Zhao; Meng Wang; Ho-pi Lin; John Duan; Lawrence Yu; Paul Seo
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Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link—a Workshop Summary ReportNARA Subscribed
The AAPS Journal · 2019 · Vol. 21 · Issue 2 · Springer
Tycho Heimbach; Sandra Suarez-Sharp; Maziar Kakhi; Nico Holmstock; Andrés Olivares-Morales; Xavier Pepin; Erik Sjögren; Eleftheria Tsakalozou; Paul Seo; Min Li; Xinyuan Zhang; Ho-Pi Lin; Timothy Montague; Amitava Mitra; Denise Morris; Nikunjkumar Patel; Filippos Kesisoglou
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Dissolution Testing in Drug Product Development: Workshop Summary ReportNARA Subscribed
The AAPS Journal · 2019 · Vol. 21 · Issue 2 · Springer
Andreas Abend; David Curran; Jesse Kuiper; Xujin Lu; Hanlin Li; Andre Hermans; Pramod Kotwal; Dorys A. Diaz; Michael J. Cohen; Limin Zhang; Erika Stippler; German Drazer; Yiqing Lin; Kimberly Raines; Lawrence Yu; Carrie A. Coutant; Haiyan Grady; Johannes Krämer; Sarah Pope-Miksinski; Sandra Suarez-Sharp
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Comparison of Intestinal Absorption and Disposition of Structurally Similar Bioactive Flavones in Radix ScutellariaeNARA Subscribed
The AAPS Journal · 2012 · Vol. 14 · Issue 1 · Springer
Chenrui Li; Li Zhang; Limin Zhou; Siu Kwan Wo; Ge Lin; Zhong Zuo
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Hepatic Metabolism and Disposition of Baicalein via the Coupling of Conjugation Enzymes and Transporters—In Vitro and In Vivo EvidencesNARA Subscribed
The AAPS Journal · 2011 · Vol. 13 · Issue 3 · Springer
Li Zhang; Chenrui Li; Ge Lin; Peter Krajcsi; Zhong Zuo
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Therapeutic MicroRNA Strategies in Human CancerNARA Subscribed
The AAPS Journal · 2009 · Vol. 11 · Issue 4 · Springer
Chunsheng Li; Yi Feng; George Coukos; Lin Zhang
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The role of halogen substitution in classical cannabinoids: A CB1 pharmacophore modelNARA Subscribed
The AAPS Journal · 2004 · Vol. 6 · Issue 4 · Springer
Spyros P. Nikas; Jolanta Grzybowska; Demetris P. Papahatjis; Avgui Charalambous; Ali R. Banijamali; Ravi Chari; Pusheng Fan; Therapia Kourouli; Sonyuan Lin; Albert J. Nitowski; Gilbert Marciniak; Yan Guo; Xiuyan Li; Chia-Lin J. Wang; Alexandros Makriyannis
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Formulation design of double-layer in the outer shell of dry-coated tablet to modulate lag time and time-controlled dissolution function: Studies on micronized ethylcellulose for dosage form design (VII)NARA Subscribed
The AAPS Journal · 2004 · Vol. 6 · Issue 3 · Springer
Shan-Yang Lin; Kung-Hsu Lin; Mei-Jane Li
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