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210Pb-Derived Bioturbation Rates in Sediments Around Seamounts in the Tropical Northwest PacificOA Marine
To evaluate bioturbation coefficients (D B ) and mixing depths (L), 210 Pb and 226 Ra activity was measured in two sediments cores (from water depths of 5,398 m and 4,428 m), which were collected from seamount areas in the Northwest Pacific. Using a steady-state diffusion mode, we estimated D B values of 16.8 and 24.1 cm 2 /a, higher than those in abyssal sediments and those predicted by traditional empirical equations. Corres...
Vertical axial flow pump device has the characteristics of large flow and low head, which is widely used in pumping station projects with head of 3–9 m. In order to study the influence of the timing effect of the impeller relative flow channel and guide vane on the flow field and pulsation in the axial flow pump device, the whole flow channel of the vertical axial flow pump device was taken as the research object. The reliabil...
Species Composition and Assemblages of Ichthyoplankton in Sansha Bay, Fujian Province, ChinaOA Marine
Sansha Bay (26.40−27.00°N, 119.50−120.20°E) is a typical semi-enclosed bay, located in northern Fujian Province, China, and adjacent to the East China Sea. The ichthyoplankton species composition and assemblage structure were investigated based on monthly sampling at 25 stations in April−September 2019, covering the important spring and summer spawning seasons in the region. Sampling was conducted in the first 3−5 days of the...
The Key Regulator of Necroptosis, RIP1 Kinase, Contributes to the Formation of Astrogliosis and Glial Scar in Ischemic StrokeNARA Subscribed
Necroptosis initiation relies on the receptor-interacting protein 1 kinase (RIP1K). We recently reported that genetic and pharmacological inhibition of RIP1K produces protection against ischemic stroke-induced astrocytic injury. However, the role of RIP1K in ischemic stroke-induced formation of astrogliosis and glial scar remains unknown. Here, in a transient middle cerebral artery occlusion (tMCAO) rat model and an oxygen and...
Prader–Willi syndrome (PWS) is a rare genetic disorder associated with developmental delay, obesity, and neuropsychiatric comorbidities. Limosilactobacillus reuteri ( Lactobacillus reuteri , Lact. reuteri ) has demonstrated anti-obesity and anti-inflammatory effects in previous studies. In the present study, we aim to evaluate the effects of Lact. reuteri supplementation on body mass index (BMI), social behaviors, and gut micr...
Saikosaponin-d alleviates hepatic fibrosis through regulating GPER1/autophagy signalingNARA Subscribed
Background Hepatic fibrosis is the final pathway of chronic liver disease characterized by excessive accumulation of extracellular matrix (ECM), which eventually develop into cirrhosis and liver cancer. Emerging studies demonstrated that Saikosaponin-d (SSd) exhibits a protective role in liver fibrosis. However, the mechanism underlying anti-liver fibrosis of SSd in vivo and in vitro remains unclear. Methods and results Transf...
Microglia activation and associated inflammation are implicated in the periventricular white matter damage (PWMD) in septic postnatal rats. This study investigated whether melatonin would mitigate inflammation and alleviate the axonal hypomyelination in the corpus callosum in septic postnatal rats. We further explored if this might be related to the modulation of microglial polarization from M1 phenotype to M2 through the JAK2...