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Journal: Archives of Virology ×Author: Li-Rong Yang ×Clear All Filters
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Archives of Virology · 2023 · Vol. 168 · Issue 2 · Springer
The intron-based stabilization approach is a very useful strategy for construction of stable flavivirus infectious clones. SA 14 -14-2 is a highly attenuated Japanese encephalitis (JE) live vaccine strain that has been widely used in China since 1989. To develop safe and effective recombinant vaccines with SA 14 -14-2 as a backbone vector, we constructed the DNA-based infectious clone pCMW-JEV of SA 14 -14-2 using the intron-b...