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Springer Nature1
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✓Human Cell1
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20261
Li-Sheng Yu results 1 · Newest (Page 1/1, per page 25)
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Journal: Human Cell ×Author: Li-Sheng Yu ×Clear All Filters
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Ethambutol induces optic neuropathy through SDHB-mediated ferroptosis in retinal ganglion cells via Smad4 pathwayNARA Subscribed
Human Cell · 2026 · Vol. 39 · Issue 2 · Springer
Qiushi Li; Wei Ge; Yifan Zhang; Qibin Xu; Junli Xu; Yu Zhang; Xingneng Guo; Wenyan Sheng; Liwei Zhu
Ethambutol (EMB)-induced optic neuropathy (EON) is a clinical concern. Ferroptosis, involving iron and toxic reactive oxygen species (ROS), causes unique cell death, but its mechanism in EON is unclear. This study aims to explore the EON mechanisms. Wistar rats were used to establish an EON model by administering EMB at 50 mg/kg daily for 8 weeks. Retinal ganglion cells (RGC-5 cells) were used for in vitro experiments. Histolo...
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