Alzheimer’s Disease (AD) is a complex polygenic neurodegenerative disorder. Its genetic risk’s relationship with all-cause dementia may be influenced by the plasma proteome. Up to 40,139 UK Biobank participants aged ≥ 50y at baseline assessment (2006–2010) were followed-up for ≤ 15 y for dementia incidence. Plasma proteomics were performed on a sub-sample of UK Biobank participants ( k = 1,463 plasma proteins). AD polygenic ri...