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Science China Life Sciences · 2025 · Vol. 68 · Issue 11 · Springer
Alternative polyadenylation (APA) is a pervasive mechanism that is emerging as a formidable player in post-transcriptional regulation. The transcriptional landscape can be altered via APA in response to various stimulating factors. Using the PacBio single-molecule long-read sequencing method, we present for the first time the 3′UTR landscape and reveal a global increase of APA events in prostate cancer (PCa) LNCaP cells in res...