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Age-dependent modulations of hemispheric small-world networks in different eye states: resting-state electroencephalogram researchNARA Subscribed
Normal aging triggers substantial topological transformation within resting-state electroencephalography (rs-EEG) networks. Given that the small-world (SW) architecture of hemispheric EEG networks may reflect an evolutionarily and developmentally optimized organization, investigating their modulations with age offers critical insights into the dynamic reorganization of functional connectivity (FC) patterns throughout adulthood...
Alzheimer’s disease polygenic risk’s association with all-cause dementia through the plasma metabolome in the UK Biobank studyNARA Subscribed
Dementia, with Alzheimer’s Disease (AD) accounting for 60–70% of its occurrences, is a multifactorial disorder marked by cognitive and functional decline. Polygenic risk scores (PRS) stratify genetic risk for complex diseases, including AD. Integrating PRS with metabolomics offers a pathway to better understand AD etiology and identify biomarkers for early detection. We explored the association between AD PRS, metabolomics, an...
Alzheimer’s Disease polygenic risk, the plasma proteome, and dementia incidence among UK older adultsNARA Subscribed
Alzheimer’s Disease (AD) is a complex polygenic neurodegenerative disorder. Its genetic risk’s relationship with all-cause dementia may be influenced by the plasma proteome. Up to 40,139 UK Biobank participants aged ≥ 50y at baseline assessment (2006–2010) were followed-up for ≤ 15 y for dementia incidence. Plasma proteomics were performed on a sub-sample of UK Biobank participants ( k = 1,463 plasma proteins). AD polygenic ri...
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