Microbes in the sea surface microlayer (SML) are key to connecting the ocean and the atmosphere, affecting the exchange of matter, momentum, and heat at the interface. However, their sources have never been quantified systematically. Seawater has long been deemed their major source, whereas atmospheric deposition is regarded as trivial or merely providing additional nutrients. Here, combining atmospheric observations and quant...

Ship pipeline selection, as a crucial component of ship pipeline design, is often a time-consuming process due to its high complexity. In this study, the response surface methodology combined with the multi-objective particle swarm optimization algorithm was used to optimize the fuel pipeline resistance and its space volume, aiming to select the optimal design scheme for an X-type replenishment oiler. Firstly, a one-dimensiona...

Iberdomide is a BCS III CELMoD™ agent currently under development for treatment of multiple myeloma. Five formulations were used during clinical development, starting with active ingredient in gelatin capsule (AIC), followed by subsequent formulations in gelatin (F1), HPMC capsules (F2 and F3), and finally the intended commercial form (ICF). A food effect study with the Phase I AIC formulation showed no food effect and two rel...