Hepcidin is a cysteine‐rich peptide that functions both as an antimicrobial peptide and a central regulator of iron homeostasis in vertebrates. Structurally, it consists of an N‐terminal signal peptide, a propeptide region and a C‐terminal bioactive mature peptide. The canonical mature hepcidin contains eight conserved cysteine residues that form four disulfide bonds, stabilising a characteristic β‐sheet hairpin‐like structure...

The molecular mechanisms underlying the adaptation to freshwater habitats in fish of marine origin remain unclear. Grenadier anchovies, such as Coilia nasus , originate from marine environments and include both anadromous and freshwater‐resident conspecifics, making them ideal for studying adaptive evolution from marine to freshwater habitats. We conducted a comparative population genomic and transcriptome analysis of two dist...

Hepcidin is a key regulator of systemic iron homeostasis, which is essential for maintaining iron balance and cellular health. To investigate its role in zebrafish, we empolyed a hepcidin knockout model. Morphological and histological analyses revealed pale livers and significant iron accumulation in hep−/− zebrafish, particularly in liver, skin, and egg tissues. RNA sequencing identified 1,424 differentially expressed genes (...

Introduction The carbonate-evaporite system contains substantial hydrocarbon resources and serves as an excellent subject for studying dolomitization problem. In the Ordos Basin, the fifth member of the Ordovician Majiagou Formation have extensive carbonate-evaporite deposits. Methods This study utilizes extensive drilling data, thin section microscopic examination, scanning electron microscopy, and a variety of geochemical an...

Takifugu obscurus (pufferfish) is an important species in aquaculture and has become widely popular in China and Japan. However, the development of the pufferfish aquaculture industry has been significantly impacted by severe diseases. Fish cell lines, as a model for in vitro studies, have the advantages of low cost, easy culture, and low genetic variation rate. A novel cell line from the fin of T. obscurus was established in...

Temperature is a leading environmental factor determining the sex ratio of some animal populations, such as fish, amphibians, and reptiles. However, the underlying mechanism by which temperature affects gender is still poorly understood. Transient receptor potential a1b (Trpa1b) belongs to the ion channel family of transient receptor potentials and exhibits dual thermosensitivity to heat and cold. In this study, we have unveil...

Liver‐expressed antimicrobial peptide 2 (LEAP2) is a small peptide, which is consisted of signal peptide, pro‐peptide and the bioactive mature peptide. Mature LEAP2 is an antibacterial peptide with four highly conserved cysteines forming two intramolecular disulfide bonds. Chionodraco hamatus , an Antarctic notothenioid fish that lives in the coldest water, has white blood unlike most fish of the world. In this study, the LEAP...