An increasing number of epidemiological studies have suggested that birth weight (BW) may be a determinant of bone health later in life, although the underlying genetic mechanism remains unclear. Here, we applied a pleiotropic conditional false discovery rate (cFDR) approach to the genome-wide association study (GWAS) summary statistics for lumbar spine bone mineral density (LS BMD) and BW, aiming to identify novel susceptibil...

The Antarctic krill ( Euphausia superba ) fishery is the largest fishery in the Southern Ocean, and it has been operating for over 45 years. In the past decade, the spatial distribution of the krill fishery has focused on the Bransfield Strait off the Antarctic Peninsula (subarea 48.1). However, the high fishing effort and climate change have placed great pressure on krill resources in this region, and conservation concerns ha...

Exposure to chronic hypoxia is considered to be a risk factor for deficits in brain function in adults, but the underlying mechanisms remain largely unknown. Since active myelinogenesis persists in the adult central nervous system, here we aimed to investigate the impact of chronic hypoxia on myelination and the related functional consequences in adult mice. Using a transgenic approach to label newly-generated myelin sheaths (...