Chronic kidney disease (CKD) affects over 850 million people worldwide and is characterized by progressive renal fibrosis driven by activated interstitial fibroblasts. Signaling by extracellular nucleotides and P2 receptors plays an important role in renal pathophysiology, yet its contribution to fibroblast activation and fibrosis remains poorly understood. Here, we investigated the expression and function of G q/11 -coupled P...

Thirty lactic acid bacteria (LAB) isolates were obtained from the digestive tracts of whiteleg shrimp ( Penaeus vannamei ) and screened for antagonistic activity against Vibrio parahaemolyticus , the causative agent of Acute Hepatopancreatic Necrosis Disease (AHPND). Among these, four isolates demonstrated strong inhibitory effects, producing inhibition zones of 16–20 mm in agar well diffusion assays. These four LAB isolates w...