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Glioblastoma (GBM) is the most common malignant brain tumor and has the poorest prognosis attributed to its chemoresistance to temozolomide (TMZ), the first-line drug for treating GBM. TMZ resistance represents a significant obstacle to successful GBM treatment, necessitating the development of new strategies to overcome this resistance and augment the chemosensitivity of GBM cells to TMZ. This study established a TMZ-resistan...
The contribution of high-frequency wind to the Peruvian upwelling system during 2014–2016 was studied using the Regional Ocean Modeling System (ROMS), forced by four different temporal resolution (six-hourly, daily, weekly, and monthly) wind forcing. A major effect of the high-frequency wind is its warming of the water at all depths along the Peruvian coast. The mechanism for the temperature changes induced by high-frequency w...
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