Background There is lack of research on corticosteroid use for severe and critical COVID-19 patients with Omicron variant infection. Methods This multi-center retrospective cohort study involved 1167 patients from 59 ICUs across the mainland of China diagnosed with severe or critical SARS-CoV-2 Omicron variant infection between November 1, 2022, and February 11, 2023. Patients were segregated into two groups based on their cor...

Background Rheumatoid arthritis (RA) is an autoimmune inflammation disease characterized by imbalance of immune homeostasis. p53 mutants are commonly described as the guardian of cancer cells by conferring them drug-resistance and immune evasion. Importantly, p53 mutations have also been identified in RA patients, and this prompts the investigation of its role in RA pathogenesis. Methods The cytotoxicity of disease-modifying a...

Aim The interactions between plants and soil microbes play crucial roles in modulating the function and stability of terrestrial ecosystems. However, the relationships between plant and soil microbial diversity for different taxa have remained been elusive. Location Northern China. Major taxa Plant and soil microbes of grassland ecosystems. Time period 2018 and 2019. Methods We conducted a transect survey across grasslands to...