Lisa Jackson results 39
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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Flatfishes are important components of benthic communities and support small-scale fisheries that sustain livelihoods in the southwestern Indian Ocean. However, limited data on their diversity and distribution hinder effective management and conservation, especially under growing threats from destructive fishing and climate change. To address this, 134 flatfish specimens from the Tanzanian coast were analyzed. Specimens were i...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Pedigree‐Informed Abundance Estimation for the Endangered North Atlantic Right Whale ( Eubalaena glacialis ) via Gametic Mark‐RecaptureNARA Subscribed
Pedigrees can provide important data for abundance estimation by providing a means to infer the presence of individuals that might otherwise not be detected. Such information may be particularly important for endangered species, where the addition or removal of just a few individuals can make the difference between population growth and decline. Here, we use gametic mark‐recapture methods to incorporate pedigree information in...
Evaluating the Use of Environmental DNA for Pinniped Detection and Population Genetics at Haulout SitesNARA Subscribed
Population genetics is an important tool in marine resource management, but the collection of genetic data for marine mammals can be physically invasive and logistically challenging. Environmental DNA (eDNA) provides a non‐invasive method for monitoring the presence of marine mammals. However, effective applications are limited by gaps in our knowledge about how eDNA behaves in the marine environment, and its use for populatio...
A Scoping Review of Mosquito Vector Range Shifts: Widespread Expansions and Evidence Gaps in Climate AttributionNARA Subscribed
As global temperatures rise, concerns about shifting mosquito ranges—and accompanying changes in the transmission of malaria, dengue, and other diseases—are mounting. However, systematic evidence for climate‐driven changes in mosquito ranges remains limited. We conducted a scoping review following PRISMA ‐ ScR guidelines of studies documenting expansions or contractions in medically important mosquito species. In total, 178 st...
Disease-driven collapse of the native Kauaʻi avifauna and the rise of introduced bird speciesNARA Subscribed
Hawaii hosts one of Earth’s most unique and threatened avifaunas. Upslope migration of mosquito-vectored avian malaria on Kauaʻi (maximum elevation 1,598 m) has likely caused its rapid loss of avifaunal diversity; only 8 of 13 historic forest bird species remain. We update the status and trends of Kauaʻi forest bird populations since the original (1981) surveys using the latest (2023) survey data and distance sampling. We fit...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Beach ridges originate from various depositional processes and occur in a variety of settings. This paper assesses their nature and distribution on the islands of the Greater Caribbean based on a literature review and the identification of sites using Google Earth© 7.3 imagery. The morphological and orientation parameters were measured for each site, and a measure of storm density was developed. These were statistically analys...
A combination nutritional supplement reduces DNA methylation age only in older adults with a raised epigenetic ageNARA Subscribed
An increase in systemic inflammation (inflammaging) is one of the hallmarks of aging. Epigenetic (DNA methylation) clocks can quantify the degree of biological aging and this can be reversed by lifestyle and pharmacological intervention. We aimed to investigate whether a multi-component nutritional supplement could reduce systemic inflammation and epigenetic age in healthy older adults. We recruited 80 healthy older participan...
Anegada, the easternmost island of the Virgin Islands group (Caribbean Sea), is a low Pleistocene carbonate platform surrounded by Horseshoe Reef, the world’s third-largest fringing reef. The western part of the island consists of an extensive beachridge plain (>40 ridges). The sandy carbonate shoreline exists in three morphodynamic domains that exhibit distinctive behaviour over the 59-year study period (1953 to 2012). The no...
Targeting de novo loss-of-function variants in constrained disease genes improves diagnostic rates in the 100,000 Genomes ProjectNARA Subscribed
Background Genome sequencing was first offered clinically in the UK through the 100,000 Genomes Project (100KGP). Analysis was restricted to predefined gene panels associated with the patient’s phenotype. However, panels rely on clearly characterised phenotypes and risk missing diagnoses outside of the panel(s) applied. We propose a complementary method to rapidly identify pathogenic variants, including those missed by 100KGP...
While photo-identification is an effective tool to monitor individuals in wild populations, it has limitations. Specifically, it cannot be applied to very young animals before their identifying features have stabilized or to dead, decomposed animals. These shortfalls leave gaps in our understanding of survival, parentage, age structure, physical development, and behavioral variability. Here we report on 13 case studies of Nort...