Vibrio parahaemolyticus , a ubiquitous pathogen in marine and estuarine environments, is a foodborne microorganism whose infections have become a global public health challenge. In recent years, the overuse and misuse of antibiotics have led to the emergence of increasing numbers of antibiotic‐resistant strains of V. parahaemolyticus worldwide. These strains harbor resistance genes that mediate various resistance mechanisms, p...

Summary Acyltransferase (AT)‐less type I polyketide synthases (PKSs) produce complex natural products due to the presence of many unique tailoring enzymes. The 3‐hydroxy‐3‐methylglutaryl coenzyme A synthases (HCSs) are responsible for β ‐alkylation of the growing polyketide intermediates in AT‐less type I PKSs. In this study, we discovered a large group of HCSs, closely associated with the characterized and orphan AT‐less type...