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NARA Subscribed2
Publisher
Springer Nature2
Journal
Histochemistry and Cell Biology1
Pharmaceutical Research1
Publication Year
20201
19991
Louis Boon results 2 · Newest (Page 1/1, per page 25)
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Sialic Acid-Engineered IL4–10 Fusion Protein is Bioactive and Rapidly Cleared from the CirculationNARA Subscribed
Pharmaceutical Research · 2020 · Vol. 37 · Issue 2 · Springer
Cristine Steen-Louws; Peter Boross; Judith Prado; Jan Meeldijk; Jurgen B. Langenhorst; Alwin D. R. Huitema; Marcel T. den Hartog; Louis Boon; Floris P. J. G. Lafeber; C. Erik Hack; Niels Eijkelkamp; Jelena Popov-Celeketic
Purpose Modulating sialylation of therapeutic glycoproteins may be used to influence their clearance and systemic exposure. We studied the effect of low and high sialylated IL4–10 fusion protein (IL4–10 FP) on in vitro and in vivo bioactivity and evaluated the effect of differential sialylation on pharmacokinetic parameters. Methods CHO cell lines producing low (IL4–10 FP lowSA) and high sialylated (IL4–10 FP highSA) fusion pr...
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High protein diet induces pericentral glutamate dehydrogenase and ornithine aminotransferase to provide sufficient glutamate for pericentral detoxification of ammonia in rat liver lobulesNARA Subscribed
Histochemistry and Cell Biology · 1999 · Vol. 111 · Issue 6 · Springer
Louis Boon; Willie J. C. Geerts; A. Jonker; Wouter H. Lamers; Cornelis J. F. Van Noorden
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