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The capacity to retain long-term functional algal chloroplasts within animal cells is a singular trait of certain Sacoglossa sea slugs. The sequestered chloroplasts (kleptoplasts) confer photosynthetic capacity to the host. Photosynthetic organisms possess distinctive lipid classes that are essential for chloroplast membrane integrity and photosynthetic function. This study investigated how chloroplast lipidomes from two macro...
The increasing use of probiotics in dietary supplements and functional foods highlights the need for robust analytical strategies to assess microbial viability, functional performance, and safety. Conventional culture-based methods may underestimate probiotic potential, particularly in multi-strain formulations. In this study, a multi-analytical framework was applied to evaluate four commercial formulations containing Lactobac...
Cognition-oriented treatments (COTs) are a group of non-pharmacological treatments aimed at maintaining or improving cognitive functioning. Specific recommendations on the use of these interventions in people living with dementia (PLwD) are included in the Italian Guideline on the Diagnosis and Treatment of Dementia and Mild Cognitive Impairment, developed by the Italian National Institute of Health. This systematic review and...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
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