Mouse models with complex genetic backgrounds are increasingly used in preclinical research to accurately model human disease and to enable temporal and cell-specific evaluation of genetic manipulations. Backcrossing mice onto these complex genetic backgrounds takes time and leads to significant wastage of animals. In this study, we aimed to evaluate whether site-specific nucleases could be used to generate additional genetic...

Accessory vessels, including platters, dishes, beakers, flagons, jars, and amphorae, are a common feature of Romano-British burials, raising questions as to their provenance; for example, were such vessels recycled from the domestic sphere or made specially for funerary purposes? Furthermore, uncertainty surrounds their purpose: did they contain foods for the deceased, possibly for their final journey to the underworld? Intere...

Over the course of the last decade the concept of the Anthropocene has become widely established within and beyond the geoscientific literature but its boundaries remain undefined. Formal definition of the Anthropocene as a chronostratigraphical series and geochronological epoch following the Holocene, at a fixed horizon and with a precise global start date, has been proposed, but fails to account for the diachronic nature of...

Recognizing the imperative to evaluate species recovery and conservation impact, in 2012 the International Union for Conservation of Nature (IUCN) called for development of a “Green List of Species” (now the IUCN Green Status of Species). A draft Green Status framework for assessing species’ progress toward recovery, published in 2018, proposed 2 separate but interlinked components: a standardized method (i.e., measurement aga...

The genital mycoplasmas are a unique group of inherently antibiotic-resistant sexually transmitted bacteria, often associated with non-gonococcal urethritis and bacterial vaginosis. The MYCO WELL D-ONE is a culture-based assay that aims to detect these organisms whilst concurrently screening them for antibiotic resistance. Urine and/or swabs from 856 informed and consented participants attending Welsh sexual health clinics wer...

Aim The relationship of population genetics with the ecology and biogeography of species may be explored by comparing phenotypically similar but ecologically different congeners with overlapping ranges. We compared genetic differentiation between two congeneric rocky intertidal gastropods across a major portion of their sympatric range. We hypothesized that the habitat generalist with high abundance and continuous distribution...

The rise of food security up international political, societal and academic agendas has led to increasing interest in novel means of improving primary food production and reducing waste. There are however, also many ‘post-farm gate’ activities that are critical to food security, including processing, packaging, distributing, retailing, cooking and consuming. These activities all affect a range of important food security elemen...