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Springer Nature1
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GeroScience1
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20231
Luke Spray results 1 · Newest (Page 1/1, per page 25)
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Activation of telomerase by TA-65 enhances immunity and reduces inflammation post myocardial infarctionNARA Subscribed
GeroScience · 2023 · Vol. 45 · Issue 4 · Springer
Bilal Bawamia; Luke Spray; Vincent K. Wangsaputra; Karim Bennaceur; Sharareh Vahabi; Konstantinos Stellos; Ehsan Kharatikoopaei; Emmanuel Ogundimu; Chris P. Gale; Bernard Keavney; Rebecca Maier; Helen Hancock; Gavin Richardson; David Austin; Ioakim Spyridopoulos
Myocardial infarction (MI) accelerates immune ageing characterised by lymphopenia, expansion of terminally differentiated CD8 + T-lymphocytes (CD8 + T EMRA ) and inflammation. Pre-clinical data showed that TA-65, an oral telomerase activator, reduced immune ageing and inflammation after MI. We conducted a double blinded randomised controlled pilot trial evaluating the use of TA-65 to reduce immune cell ageing in patients follo...
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