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Vascular contribution to cognitive impairment and dementia (VCID): proceedings of 2025 workshop of the Jackson LaboratoryNARA Subscribed
The first Vascular Contributions to Cognitive Impairment and Dementia (VCID) Workshop, held on May12-16, 2025 at The Jackson Laboratory, provided scientific content and career development training in the latest developments in VCID and Alzheimer’s Disease (AD) and related dementia (ADRD). The Workshop aimed to foster interdisciplinary collaborations and empower the next generation of diverse scientists to advance ADRD research...
“It's a good reason to get up every morning!”: Perspectives on how feeding and observing birds affects people’s wellbeingNARA Subscribed
In light of growing mental health challenges globally, understanding the positive impacts of nature on mental wellbeing is more important than ever. However, the impacts of one of the most common intentional human–wildlife interactions, feeding wild birds, are not well understood. We surveyed 3658 participatory scientists in the USA and Canada who take part in Project FeederWatch to examine associations between wellbeing and b...
Background Currently, no single biomarker can reliably identify preclinical Alzheimer’s disease (AD), particularly at or before the mild cognitive impairment (MCI) stage. Given the heterogeneity of MCI, integrative approaches are needed to improve early risk stratification. Objectives (i) To derive robust latent cognitive components from a multicenter, clinically defined MCI cohort using principal component analysis (PCA); (ii...
Untargeted Metabolomics Reveals Major Patterns of Metabolic Shifts in Potato Seed Tubers during StorageNARA Subscribed
To obtain comprehensive insight into metabolic changes in potato seed tubers during storage and to identify patterns associated with physiological ageing, we analysed tuber metabolite composition using untargeted metabolomics based on gas and liquid chromatography-mass spectrometry (GC–MS and LC–MS). During two seasons, seed tubers of four contrasting cultivars (Agria, Festien, Innovator, and Lady Claire) were produced in a si...
Nature-based solutions (NbS) scholarship is overshooting its most basic purpose—the implementation of NbS projects. Investment in high-level design is outpacing the practical realities of implementation. While expert-driven approaches are useful for project prioritization at landscape scales, all NbS projects are implemented in real places, inhabited by human and non-human lives. Projects span multiple properties, impact resid...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...