Purpose Breast cancer is a significant global health issue, with resistance to doxorubicin (DOX) posing a major challenge to effective treatment. SUMOylation, a post-translational modification process, is linked to cancer progression and therapy resistance. PIAS4, a SUMO E3 ligase involved in maintaining genome stability and stress response, may play a role in these mechanisms. However, its function in breast cancer progressio...

The purpose of the study is to evalute the in vivo anti -inflammatory activity of newly synthesized cyanoacetate derivatives of succinimides (C-23, C-31, and C-44) and to elucidate their possible mechanisms of action through key inflammatory mediator pathways. Anti-inflammatory activity was assessed using carrageenan-induced paw oedema and arachidonic acid-induced ear oedema models in vivo. Mechanistic involvement was investig...

The Asia region harbors exceptional chondrichthyan (shark, ray, and chimaera) diversity but faces intense fishing pressure. The Important Shark and Ray Areas (ISRA) process provides a collaborative, evidence-based framework to identify critical habitats and inform spatial management. We assessed ISRAs across the Bay of Bengal, Southeast Asia, and the Northwest Pacific to characterize their extent, ecological significance, and...

Fungal pathogens pose a serious threat to the cultivation of morels ( Morchella spp.), impacting both yield and quality and, consequently, the economic viability of morel farming. This review explores the diverse range of fungal pathogens affecting morels, including Albomorchellophila morchellae , Cladobotryum protrusum , Clonostachys aureofulvella , Clonostachys rosea , Cylindrodendrum alicantinum , Diploöspora longispora , F...