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Understanding how genetic variants influence disease risk through molecular mechanisms remains a central challenge in complex disease genetics. Nonsyndromic orofacial clefts (OFCs) exemplify this challenge, with most risk loci residing in non-coding regions. We hypothesized that common genetic variants influence OFC risk by modulating DNA methylation at regulatory elements through methylation quantitative trait loci (meQTLs)....
Global patterns and regional insights into kelp forest protection, restoration, and stewardshipNARA Subscribed
Kelp forests are among the most extensive and productive coastal ecosystems, yet they remain underrepresented in global conservation policy despite widespread declines driven by interacting global- (i.e., ocean warming, marine heatwaves) to local-scale stressors. At the same time, kelp conservation and restoration efforts are expanding rapidly across regions, but measures of success and syntheses tend to primarily focus on eco...
Icon simulations suggest model-dependent cloud feedbacks in global storm-resolving modelsNARA Subscribed
Climate feedbacks, key determinants of Earth’s temperature response to radiative forcing, remain uncertain, largely because of challenges in representing cloud and convective processes. Global storm-resolving models (GSRMs), which explicitly simulates storm-scale convective circulations, have recently emerged as a promising alternative to conventional general circulation models to reduce uncertainties in clouds, convection, an...
Primary productivity and trophic interactions are fundamentally linked. However, it remains largely unknown how food web structure varies along primary productivity gradients at continental scales or how the influence of primary productivity on food webs varies within regions. Furthermore, anthropogenic pressure threatens the integrity of food webs globally with potentially predictable food web disassembly. Here, we test how p...
The domestication of crops leads to profound changes on plant phenotypes, yet its effects on floral traits mediating plant-pollinator interactions remain poorly understood. Floral volatile organic compounds (VOCs) play a crucial role in pollinator attraction by signaling the presence and quality of available floral resources. Here, we characterize VOC composition in Cucurbita , a genus containing multiple wild and domesticated...
Role of viral coinfection in post-pandemic invasive Group A streptococcal infections in adults, a nation-wide cohort study (iGASWISS)NARA Subscribed
Objective During the winter season of 2022–2023, numerous countries experienced a surge in invasive Streptococcus pyogenes (iGAS) infections. The role of viral coinfections in the post-COVID surge has not been elucidated. We report nation-wide data describing clinical presentation, microbiological characteristics, and associations with viral infection in adults during this period. Methods A multicenter retrospective cohort stu...
Hepatocellular carcinoma (HCC) is the most common primary liver tumor, often arising in the context of chronic liver disease. Despite recent advances in systemic therapies, including the use of immune checkpoint inhibitors (ICIs), clinical outcomes remain suboptimal, with many patients exhibiting primary or acquired resistance. Accumulating evidence indicates that the dysregulation of epigenetic mechanisms contributes to HCC d...
Our primary objective was to compile a comprehensive dataset on bird–window collisions throughout the Neotropical region, including both published and unpublished sources. On May 12, 2020, we extensively disseminated invitations to provide data via email and social media platforms. By providing a template worksheet, we required standardized information from collaborators to complete and register their data. To better understan...
Narratives for Positive Nature Futures in EuropeNARA Subscribed
The Nature Futures Framework (NFF) is a novel approach for the development of positive scenarios centered on the relationship of nature and people, emphasizing biodiversity as part of the solution to environmental challenges across various spatial and temporal scales, explicitly addressing a plurality of values for nature. In this work, we describe the process that has led to the formulation of continental-scale positive narra...
SNAPSHOT USA 2019–2023: The First Five Years of Data From a Coordinated Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multicontributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of specie...